Cardiplot Dosage/Direction for Use

The adult dose is 10 to 20 mg once daily in the morning after breakfast. The recommended starting dose is 10 mg daily. The dose may be increased to 20 mg daily if the antihypertensive effect is inadequate after 2 to 4 weeks. Avoid abrupt withdrawal of calcium channel blocker therapy if possible. Hypertensive crisis has been reported.
Dosage in renal failure: No dosage adjustment is required in patients with mild to moderate renal dysfunction, however caution is advised when increasing the dose from 10 to 20 mg daily.
Dosage in hepatic insufficiency: The data suggest that patients with hepatic insufficiency are at an increased risk of accumulation of manidipine, and that dose reductions should be considered in this population. The dose in patients with mild hepatic dysfunction should not exceed 10 mg daily.
Dosage in geriatric patients: The data suggest that geriatric patients are at an increased risk of accumulation of manidipine, and that dose reductions to 10 mg daily should be considered in this population.
Manidipine may cause hypotension which may result in cerebral infarction. Should start treatment with low dose.