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Antacids: Hypermagnesemia may develop in patients on chronic renal dialysis.
Digitalis glycoside: Hypercalcemia in patients on digitalis may precipitate cardiac arrhythmias.
Verapamil: Atrial fibrillation has occurred when supplemental calcium and calciferol have induced hypercalcemia.
Cholestyramine: Intestinal absorption of vitamin D may be reduced.
Ketoconazole: Ketoconazole may inhibit both synthetic and decay of vitamin D calcitriol.
Mineral oil: Absorption of vitamin D is reduced with prolonged use of mineral oil.
Phenytoin, Phenobarbital: Endogenous synthesis of calcitriol will be inhibited. Higher doses of calcitriol may be required, if patients receive this medicine at the same time.
Thiazide diuretics: Hypoparathyroid patients who receive vitamin D that may have hypercalcemia due to Thiazide diuretics.
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