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Cardiovascular: QT interval prolongation and ventricular arrhythmia secondary to hypocalcemia have been reported.
Arrhythmia, hypotension, and worsening of heart failure have been reported in patients with impaired cardiac function.
Endocrine and metabolic: Hypocalcemia can occur and may result in life-threatening or fatal events; monitor recommended.
Not indicated for use in patients not undergoing dialysis due to an increased risk of hypocalcemia.
Hepatic: Monitoring recommended in patients with hepatic impairment.
Musculoskeletal: Adynamic bone disease may occur with intact parathyroid hormone (iPTH) levels less than 100 pg/mL.
Neurologic: Seizures have been reported and may be due to hypocalcemia; monitoring recommended.
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