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Overdose data are limited. Doses up to 300 mg daily in dialysis patients have been well-tolerated. Overdose effects are anticipated to be an extension of adverse effect following therapeutic administration.
Management of mild to moderate toxicity: Treatment is symptomatic and supportive. Correct any significant fluid and/or electrolyte abnormalities in patients with severe diarrhea and/or vomiting.
Management of severe toxicity: Treatment is symptomatic and supportive. Intravenous administration of calcium gluconate or calcium chloride may be required for significant hypocalcemia. Institute continuous cardiac monitoring and monitor ECG for evidence of QT prolongation or dysrhythmias. Treat seizures with IV benzodiazepines; barbiturates or propofol may be needed if seizures persist or reoccur.
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