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Oral: Adults: Prostate cancer, metastatic: One tablet (50 mg) once daily (in combination with an LHRH analogue).
Dosage adjustment in renal impairment: No adjustment required.
Dosage adjustment in hepatic impairment: No adjustment required for mild, moderate, or severe hepatic impairment; use caution with moderate-to-severe impairment. Discontinue if ALT >2 times ULN or patient develops jaundice.
Administration: Dose should be taken at the same time each day with or without food. Treatment for metastatic cancer should be started concomitantly with an LHRH analogue.
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