Bicatero Adverse Reactions

Adverse reaction percentages reported as part of combination regimen with an LHRH analogue unless otherwise noted.
Incidence >10%: Cardiovascular: Peripheral edema.
Central nervous system: Pain.
Endocrine & metabolic: Hot flashes, breast pain, gynecomastia.
Gastrointestinal: Constipation, nausea, diarrhea, abdominal pain.
Genitourinary: Pelvic pain, hematuria, nocturia.
Hematologic: Anemia.
Neuromuscular & skeletal: Back pain, weakness.
Respiratory: Dyspnea.
Miscellaneous: Infection.
Incidence ≥2% to 10%: Cardiovascular: Chest pain, hypertension, angina pectoris, cardiac arrest, CHF, edema, MI, coronary artery disorder, syncope.
Central nervous system: Dizziness, headache, insomnia, anxiety, depression, chills, confusion, fever, nervousness, somnolence.
Dermatologic: Rash, alopecia, dry skin, pruritus, skin carcinoma.
Endocrine & metabolic: Hyperglycemia, dehydration, gout, hypercholesterolemia, libido decreased.
Gastrointestinal: Dyspepsia, weight loss, anorexia, flatulence, vomiting, weight gain, dysphagia, gastrointestinal carcinoma, melena, periodontal abscess, rectal hemorrhage, xerostomia.
Genitourinary: Urinary tract infection, impotence, polyuria, urinary retention, urinary impairment, urinary incontinence, dysuria, urinary urgency.
Hepatic: LFTs increased, alkaline phosphatase increased.
Neuromuscular & skeletal: Bone pain, paresthesia, myasthenia, arthritis, pathological fracture, hypertonia, leg cramps, myalgia, neck pain, neuropathy.
Ocular: Cataract.
Renal: BUN increased, creatinine increased, hydronephrosis.
Respiratory: Cough, pharyngitis, bronchitis, pneumonia, rhinitis, asthma, epistaxis, sinusitis.
Miscellaneous: Flu-like syndrome, diaphoresis, cyst, hernia, herpes zoster, sepsis.