Besanta Dosage/Direction for Use

Irbesartan can be used alone or with other anti-hypertensive agents. Irbesartan can be administering with or without food. The condition of intravascular volume depletion or sodium depletion should be corrected before the administration of the drug.
For the treatment of hypertension: Dosage in adults: The recommended initial and maintenance dose is 150 mg once daily.
In case of uncontrolled hypertension with 150 mg once daily, the dose can be titrated up to 300 mg once daily or adding low dose diuretic; for such, hydrochlorothiazide, as it has been shown to have an additive effect.
The use in elderly aged more than 75 years old, patients undergoing hemodialysis and patients with volume and sodium depletion, the initial dose is 75 mg once daily. Patients not adequately treated by the maximum dose of 300 mg once daily are unlikely to derive additional benefit from a higher dose or twice-daily dosing.
Diabetic nephropathy: Therapy should be initiated at 150 mg once daily and titrated up to 300 mg daily as the preferred maintenance dose for treatment of renal disease. It can be used along with other diuretics, such as, hydrochlorothiazide.
Dosage in elderly: In patients aged more than 75 years old, the initial dose is 75 mg once daily. Dosage adjustment in elderly is not always necessary.
Dosage in children: Safety and efficacy profile of Irbesartan have not been established in children.
Dosage in renal impairment: No dosage adjustment is needed in patients with impaired renal function. An initial dose of 75 mg should be considered in volume depleted and undergoing hemodialysis patients.
Dosage in hepatic impairment: No dosage adjustment is needed in mild and moderate hepatic function impairment. However, the reports and studies on the used of the drug in severe hepatic function impairment have not been established.