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1. NSAIDs cause an increased risk of serious gastrointestinal adverse events including irritation, inflammation, ulceration, bleeding and perforation of the stomach or intestinal tract. These events may occur any time during therapy and without warning and use NSAIDs with caution in patients with a history of GI disease (ulcer or bleeding), risk for serious events is greater in elderly patients.
2. Use with caution in patients with: Impaired renal function, Dehydration, Heart failure, Liver dysfunction.
3. Use with caution in patients taken with: Diuretics, ACE inhibitors, ARBs.
Use in the Elderly: The elderly are at greater risk of renal toxicity and hyperkalemia.
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