Annoxen-S Drug Interactions

Anticoagulants, hydantoins, NSAIDs, sulfonamides or sulfonylurea: Naproxen is highly bound to plasma albumin. It thus has a theoretical potential for interaction with other albumin-bound drugs such as anticoagulants, hydantoins, NSAIDs, sulfonamides or sulfonylurea. Concomitant use of Naproxen with any of these drugs should be observed for adjustment of dose.
Selective serotonin reuptake inhibitors (SSRIs): Concomitant use of Naproxen with any of SSRIs (such as fluoxetine, paroxetine, sertraline) increases the risk of GI events.
Probenecid: The excretion of Naproxen is delayed by probenecid which inhibits the formation of glucuronide conjugates of Naproxen, as well as inhibits its renal clearance, and results in raised plasma concentration of Naproxen.
Anticoagulants and thrombolytic agents: Concomitant use of Naproxen with any of anticoagulant (such as warfarin) or thrombolytic agents (such as alteplase) increases the risk of GI bleeding.
Methotrexate: Naproxen increases plasma concentration of methotrexate and thus enhances its toxicity.
ACE inhibitors and angiotensin II receptor antagonists (ARBs): Concomitant use of NSAIDs with any ACE inhibitors (such as captopril, enalapril, lisinopril) and ARBs (such as losartan, valsartan, candesartan, irbesartan) may reduce the blood pressure response to anti-hypertensive drugs.
Beta-adrenergic blocking agents, including propranolol: Naproxen may interfere with the antihypertensive effects of beta-adrenergic blocking agents (such as propranolol, atenolol, metoprolol).
Diuretics: Concomitant use of Naproxen with any diuretics (such as furosemide, HCTZ, spironolactone) should be monitored for signs of renal failure and efficacy of the diuretic.
Sucralfate, cholestyramine: Concomitant use of Naproxen with any of these drugs may result in delayed absorption of Naproxen.