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Overdose: Hypotension is the most common overdose effect. Onset of hypotension is generally within 6 hours of ingestion.
Other effects: e.g., bradycardia, bronchospasm, cough, renal insufficiency, nephrotic syndrome, hyperkalemia, and neutropenia.
Treatment: Decontamination: Consider activated charcoal after a potentially toxic ingestion and if the patient is able to maintain airway or if airway is protected.
Hypotensive episode: IV 0.9% NaCI 10-20 ml/kg, dopamine, norepinephrine.
Naloxone is effective in animal models and several case reports.
Angiotensin Amide - IV infusion 8.5 to 18 mcg/min is effective in several case reports.
Monitoring of patient: Monitor blood pressure, continuous cardiac monitoring, electrolytes, renal function, ECG and urinalysis in symptomatic patients.
