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Use in Pregnancy & Lactation: Teratogenicity studies in both rats and rabbits have concluded that AmBisome had no teratogenic potential in these species.
No reproductive toxicity studies have been conducted with AmBisome in pregnant women. Systemic fungal infections have been successfully treated in pregnant women with conventional amphotericin without obvious effect on the fetus, but the number of cases reported has been small. Safety for use in pregnant women has not been established with AmBisome. It is not known if AmBisome is excreted in human milk. AmBisome should only be used during pregnancy and breastfeeding if the possible benefits to be derived outweigh the potential risks involved.
