AmBisome Caution For Usage

Do not reconstitute the lyophilised powder/cake with saline or add saline to the reconstituted concentrate, or mix with other drugs.
The use of any solution other than those recommended, or the presence of a bacteriostatic agent (eg, benzyl alcohol) in the solution, may cause precipitation of AmBisome.
Do not use material if there is any evidence of precipitation or foreign matter. Aseptic technique must be strictly observed in all handling, since no preservative or bacteriostatic agent is present in AmBisome, or in the materials specified for reconstitution and dilution.
Use only water for injection to reconstitute the powder/cake. Use only 5% dextrose injection to dilute the reconstituted product to the appropriate concentration for infusion. An in-line membrane filter may be used for IV infusion of AmBisome. However, the mean pore diameter of the filter should not be <1 micron.
Incompatibilities: AmBisome is not physically compatible with saline solutions and should not be mixed with other drugs or electrolytes. An existing IV line must be flushed with 5% dextrose injection prior to infusion of AmBisome. If this is not feasible, AmBisome should be administered through a separate line.