Incompatibilities: Exercise extreme caution when imipramine is used in patients with coronary thrombosis, angina pectoris, congestive heart failure, disorders of cardiac rate or rhythm or conduction, prostatic disorders with potential urinary retention and glaucoma, imipramine should be used cautiously in hyperactive or agitated patients and in epileptics or ambulatory, seriously depressed patients with suicidal tendencies. Elderly patients, children and those with circulatory liability or with cardiovascular disease should receive the drug in low dosage and under careful observation and only when a clear indication for the drug has been established.