AA Pharma Imipramine Dosage/Direction for Use

Dosage: Depression: Except in elderly patients, adolescents or children: 25mg 3 times daily, initially increased up to 150mg, if necessary. Dosage in excess of 200mg daily is not recommended for office patients. More severe, hospitalised cases may require up to 300mg daily. In elderly patients and adolescents: 30 to 40mg daily, initially increased by 10mg daily to maximum of 100mg in the elderly.
In suitable subjects, the maintenance dose may be administered in a single dose before bedtime.
For persistent, functional enuresis which has not responded to other forms of management, a therapeutic trial with imipramine may be considered for children between 5 and 15 years old, who are not mentally defective, and in whom organic causes of enuresis have been excluded. The recommended dosage for such a trial is 10 to 25mg 1 hour before bedtime for children 5 years or over. If there is no response, the dosage may be increased up to 50mg, in children 12 to 15 years old. The trial period should be 2 to 4 weeks.
If there is a relapse, the treatment can be repeated but the drug should not be given for more than 2 months without discontinuing its administration and assessing the need for further drug therapy.
Because the margin of safety is lower in children, the recommended dose should not be exceeded and the minimum effective dose should be used at all times.