Zegen Drug Interactions

Aminoglycosides: The risk of nephrotoxicity may increase when aminoglycosides and cephalosporins are given concomitantly. This has not been reported with cefuroxime use to date. Monitoring of the patient's renal function is advisable when these drugs are given together.
Probenecid: Probenecid, given together with or right before administration of cefuroxime, slows down tubular secretion of cefuroxime and produces higher and more prolonged serum cefuroxime concentrations. This drug interaction is usually used beneficially in treating gonorrhea.
Tablet: Diuretics: Studies suggest that the concomitant use of potent diuretics, including furosemide and ethacrynic acid, may increase the risk of renal toxicity with cephalosporins.
Oral Antacids: These drugs may result in lower bioavailability of cefuroxime compared with that of the fasting state and tend to cancel the effect of enhanced postprandial absorption.
Oral Contraceptives: As with other antibacterial agents, cefuroxime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Powder for Injection: Other Drugs: The patient's renal function should be carefully monitored when cefuroxime is given concurrently with diuretics because adverse renal effects may occur.
Interference with Laboratory Tests: A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedict's or Fehling's solution or with Clinitest Tablets), but not with enzyme-based tests for glycosuria (e.g., Clinistix, Tes-Tape).
As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving cefuroxime.
The presence of cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
Positive direct antiglobulin (Coombs') test results have also been reported in a few patients receiving oral cefuroxime; however, it is not clear whether the mechanism of this reaction is immunologic in nature. This phenomenon can interfere with cross matching of blood.
Powder for Injection: Transient increases in blood urea nitrogen (BUN) and/or serum creatinine concentrations and decreased creatinine clearance have been reported with cefuroxime use, although causal relationship has not been established.