Zegen Caution For Usage

Powder for Injection: Directions for Reconstitution and Parenteral Administration: See Table 8.

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Compatibility, Storage and Stability: When reconstituted as directed with Sterile Water for Injection, cefuroxime suspension for IM injection maintains satisfactory potency for 24 hours at room temperature and for 48 hours under refrigeration (5°C). Discard any unused suspension after the previously-mentioned storage periods.
After reconstitution with Sterile Water for Injection, cefuroxime sodium solutions containing 90 to 100 mg cefuroxime per mL or suspensions containing 200 to 220 mg cefuroxime per mL are stable for 24 hours at room temperature and for 48 hours under refrigeration (5°C). More dilute solutions such as 750 mg or 1.5 g dissolved in 100 mL of Sterile Water for Injection, 5% Dextrose Injection, or 0.9% Sodium Chloride Injection, also maintain satisfactory potency for 24 hours at room temperature or for 7 days under refrigeration (5°C).
These solutions may be further diluted to 1-30 mg cefuroxime per mL in the following intravenous solutions and will be stable for 24 hours at room temperature or for 7 days under refrigeration: 0.9% Sodium Chloride Injection; 5% Dextrose and 0.9% Sodium Chloride Injection; 1/6 M Sodium Lactate Injection; 5% Dextrose and 0.45% Sodium Chloride Injection; Ringer's Solution, USP; 5% Dextrose Injection; Lactated Ringer's Solution, USP; 10% Dextrose Injection; 5% Dextrose and 0.2% Sodium Chloride Injection; 10% Invert Sugar in Water for Injection.
The compatibility of aminoglycosides and cefuroxime sodium depends on several factors such as concentrations of the drugs, specific diluents used, resulting pH, and temperature. If these drugs are to be given concomitantly, it is advised that the drugs be administered at separate infusion sites.
Inspect parenteral drug products visually for particulate matter and discoloration before administration whenever solution and container permit. Like other cephalosporins, cefuroxime powder as well as solutions and suspensions tend to darken, depending on storage conditions, without adversely affecting product potency.