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Omeprazole (Zefxon) injection may interact with other drugs metabolized by mixed function oxidase. Reduced dose of these drugs: Diazepam, Warfarin and Phenytoin has been associated with concomitant use of omeprazole.
The absorption of ketoconazole or itraconazole can decrease during omeprazole treatment due to decreased intragastric acidity.
Plasma concentrations of omeprazole and clarithromycin are increased during concomitant administration.
There may be interactions with other drugs also metabolized via the cytochrome P450 enzyme system.
Increases and decreases in serum cyclosporine concentrations have been reported with concomitant administration of cyclosporine and omeprazole. The mechanism is unknown. Until more data are available, monitoring of cyclosporine levels is recommended during concomitant therapy.
The combination of disulfiram and omeprazole may cause confusion or disorientation in some patients.
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