Zefxon Dosage/Direction for Use

Omeprazole (Zefxon) injection administration once daily is recommended where oral medication is inappropriate. This produces a mean decrease over 24 hours of approximately 90%. In patients with Zollinger-Ellison syndrome the recommended initial dosage of Zefxon injection is 60 mg once daily. Higher daily doses may be required and the dose should be divided and given twice daily. For aspiration prophylaxis, Zefxon injection should be administered 1 hour before operation.
Directions for Reconstitution: For IV Injection: Dissolve Zefxon injection 1 vial with the solvent provided to get omeprazole concentration of 4 mg/mL. The IV solution should be used within 4 hours after reconstitution. Do not use if any particles are present in the reconstituted solution.
For IV infusion: Dissolve Zefxon injection 1 vial with the solvent provided to get omeprazole concentration of 4 mg/mL. Then dilute with normal saline for infusion (0.9% w/v sodium chloride) 90 mL or 5% dextrose for infusion (5% w/v of dextrose) 90 mL to make a solution of 100 mL of omeprazole with a concentration of 0.4 mg/mL. The duration of IV infusion should be 20-30 minutes. The IV solution should be used within 5 hours after reconstitution. Do not store in refrigerator and do not use if any particles are present in the reconstituted solution.
Use in children: Safety and efficacy of omeprazole in children has not been established.
Use in elderly: Normal adult dosage is recommended.
Dosage in Renal Impairment: Although pharmacokinetics may be altered in patients with renal impairment, dosage adjustment does not appear necessarily in patients with such impairment.
Dosage in Hepatic Impairment: Dosage adjustment should be considered in patients with hepatic impairment. Some clinicians recommend that such patients with hepatic impairment receiving dosage exceeding 20 mg daily should be monitored closely for possible adverse effects.