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In patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system (e.g. patients with severe congestive heart failure), treatment with angiotensin-converting-enzyme inhibitors has been associated with oliguria and progressive azotemia and (rarely) with acute renal failure and death. Irbesartan would be expected to behave similarly.
Use in Children: Safety and effectiveness in pediatric patients have not been established.
Use in Elderly: No overall differences in effectiveness or safety were observed between geriatric patients and younger patients.
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