Direction for Reconstitution: Intramuscular Administration: For 1 g vial, inject 1% Lidocaine solution (3.5 mL) into the vial and shake vial thoroughly to form solution. Do not inject intravenously if reconstituted with Lidocaine.
Intravenous Administration: Ceftriaxone injection should be administered intravenously by infusion over a period of 30 minutes. Inject Sterile Water for Injection (10 mL) into vial, shake vial thoroughly to form solution. 2 g may be dissolved in 40 mL of the following calcium-free solution. A saline solution, 0.45% NaCl and 2.5% Glucose solution, 5% Glucose solution, 10% Glucose solution, 5% Glucose solution containing 6% Dextrin solution, Hydroxyethyl starch or Water for Injection. Ceftriaxone injection should not be physically mixed with solutions containing other antimicrobial drugs into diluent solutions other than those mentioned previously, due to possible incompatibility.
Reconstituted solutions retain their physical and chemical stability for six hours or 24 hours at 25°C. As a general rule, however, the solution should be used immediately after preparation.
They range in color from pale yellow to amber, depending on the concentration and the length of storage. This characteristic of the active ingredient is of no significance for the efficacy or tolerance of the drug.
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