Vexsilva Use In Pregnancy & Lactation

Pregnancy Category B. A reproductive study has been performed in rabbits at dosed up to three to ten times the concentration of silver sulfadiazine and has revealed no evidence of harm to the fetus due to silver sulfadiazine. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly justified, especially in pregnant women approaching or at term,
It is not known whether silver sulfadiazine is excreted in human milk, however, sulfonamides are known to be excreted in human milk, and all sulfonamide derivatives are known to increase the possibility of kernicterus. Because the possibility for serious adverse reactions in nursing infants from sulfonamides, a decision should be made whether to discontinue nursing or to discontinue the drug. Taking into account the importance of the drug to the mother.