Vexsilva Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Silver sulfadiazine

Indications/Uses

Adjunct for the prevention & treatment of wound sepsis in patients w/ 2nd- & 3rd-degree burns.

Click to view Vexsilva detailed prescribing information

Dosage/Direction for Use

Apply once daily to bid to approx ¹/₁₆ inch thickness. Reapply immediately after hydrotherapy. Continue until satisfactory healing has occurred or until burn site is ready for grafting.

Click to view Vexsilva detailed prescribing information

Contraindications

Hypersensitivity to silver sulfadiazine. Should not be used on pregnant women approaching or at term due to the possibility of kernicterus, on premature or newborn infants during the first 2 mth of life.

Click to view Vexsilva detailed prescribing information

Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Vexsilva detailed prescribing information

Special Precautions

Blood dyscracias, including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia & hemolytic anemia; dermatologic & allergic reactions including SJS, TEN & exfoliative dermatitis; GI reactions; hepatitis & hepatocellular necrosis; CNS reactions & toxic nephrosis. Potential cross-sensitivity between silver sulfadiazines & other sulfonamides. Fungal proliferation in & below eschar may occur. May be hazardous to individuals w/ G6PD individuals due to hemolysis. Discontinue if hepatic & renal functions become impaired & elimination of drug decreases. Carefully monitor renal functions & check for sulfa crystals in urine. May affect interpretation of lab test affecting serum osmolality w/ propylene glycol vehicle. Discontinue nursing or drug due to possibility of kernicterus.

Click to view Vexsilva detailed prescribing information

Use In Pregnancy & Lactation

Click to view Vexsilva detailed prescribing information

Adverse Reactions

Transient leukopenia. Skin necrosis/discoloration, erythema multiforme, burning sensation, rashes & interstitial nephritis.

Click to view Vexsilva detailed prescribing information

Drug Interactions

May potentiate the effects of oral anticoagulants, MTX & phenytoin. Possibility of interactions w/ other highly protein-bound drugs eg, NSAIDs. Enhanced effects of sulfonylurea. Decrease plasma-ciclosporin conc when used concomitantly. Failures of hormonal contraceptives resulting to pregnancy. May increase risk of crystalluria w/ compounds which render urine acidic.

Click to view Vexsilva detailed prescribing information

Storage

View Vexsilva storage conditions for details to ensure optimal shelf-life.

Description

View Vexsilva description for details of the chemical structure and excipients (inactive components).

Action

View Vexsilva mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Topical Antibiotics

ATC Classification

D06BA01 - silver sulfadiazine ; Belongs to the class of topical sulfonamides used in the treatment of dermatological diseases.

Regulatory Classification

Presentation/Packing

Form

Vexsilva cream 10 mg/g (1% w/w)

Packing/Price

20 g x 1's;5 g x 1's

Vexsilva

silver sulfadiazine

Manufacturer:

Vexxa Lifesciences

Distributor:

VE Pharma