Vestar Special Precautions

Trimetazidine is not a curative treatment for angina attacks, nor an initial treatment for unstable angina pectoris. In the event of an angina attack, inform the physician. Tests may be required, and treatment regimen may be modified.
Trimetazidine is not a treatment for myocardial infarction.
Trimetazidine can cause or worsen parkinsonian symptoms (tremor, akinesia, hypertonia), especially in elderly patients.
Trimetazidine therapy should be stopped permanently in patients who develop movement disorders and neurological consultation sought if such adverse events persist for more than 4 months after discontinuation of the drug.
Falls may occur, related to gait instability or hypotension, particularly in patients taking antihypertensive drugs.
Trimetazidine should be used with caution in elderly patients and in patients with renal impairment.
Effects on Ability to Drive and Use Machine: Cases of dizziness or drowsiness have been observed in post marketing experience, which may affect the ability to drive and use machines.
Use in Children: The safety and efficacy of trimetazidine in patients below 18 years old have not been established.
Use in the Elderly: Elderly patients may have increased trimetazidine exposure due to age-related decrease in renal function. Caution is advised.