Vestar Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Trimetazidine

Indications/Uses

Adjunct treatment of stable angina pectoris inadequately controlled by or intolerant to 1st-line anti-anginal agents; CHF.

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Dosage/Direction for Use

Adult 1 tab every morning & evening. Patient w/ moderate renal impairment (CrCl 30-60 mL/min) & elderly 1 tab every morning.

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Overdosage

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Administration

Should be taken with food: Take at mealtime. Swallow whole w/ a glass of water, do not chew/crush, since this may cause inappropriate release & absorption of the drug.

Contraindications

Hypersensitivity. Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome, & other movement-related disorders. Severe renal impairment (CrCl <30 mL/min). Pregnancy & breastfeeding.

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Special Precautions

Not a curative treatment for angina attacks, nor an initial treatment for unstable angina pectoris. Not a treatment for MI. May cause or worsen parkinsonian symptoms (eg, tremor, akinesia, hypertonia), particularly in elderly. Permanently stop therapy in patients who develop movement disorders & seek neurologist consultation if movement disorders persist >4 mth after treatment discontinuation. Falls may occur, related to gait instability or hypotension, particularly in patients taking anti-hypertensive treatment. Caution in patients w/ renal impairment (CrCl 30-60 mL/min); elderly. May affect ability to drive or use machines.

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness, headache, abdominal pain, diarrhea, dyspepsia, nausea, vomiting, rash, pruritus, urticaria, & asthenia. Agranulocytosis, thrombocytopenia, thrombocytopenic purpura; parkinsonian symptoms (tremor, akinesia, hypertonia), gait instability, restless leg syndrome, other movement-related disorders (insomnia, drowsiness); palpitations, extrasystoles, tachycardia; arterial hypotension, orthostatic hypotension, flushing; constipation; hepatitis; acute generalized exanthematous pustulosis, angioedema.

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Drug Interactions

Do not co-administer w/ MAOIs.

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Storage

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Description

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Action

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MIMS Class

Anti-Anginal Drugs

ATC Classification

C01EB15 - trimetazidine ; Belongs to the class of other cardiac preparations.

Regulatory Classification

Presentation/Packing

Form

Vestar MR tab 35 mg

Packing/Price

60's (P22.03/modified-release tab)

Vestar

trimetazidine

Manufacturer:

Therapharma

Distributor:

Therapharma