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Vasoprotective.
Pharmacology: Pharmacodynamics: Veins: Diosmin + Hesperidin reduce the predisposition of veins to vasodilate and reduce venous stasis.
Lymphatic system: It stimulates the lymphatic activity, improving drainage of the interstitial space and increasing lymphatic flow.
Microcirculation: It reduces capillary permeability and increases capillary resistance.
Pharmacokinetics: Absorption: Diosmin is rapidly hydrolyzed in the intestine by intestinal flora and absorbed as its aglycone derivative, diosmetin.
Distribution: Diosmetin has a broad distribution into tissues.
Metabolism: It is extremely metabolized to phenolic acids or to its glucoronide derivatives of aglycone that are eliminated in the urine.
Elimination: It is eliminated in the urine and feces after 24-48 hours of oral administration.
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