Vaxirab N Drug Interactions

VaxiRab N can be given concurrently with other vaccines (particularly tetanus toxoid). No intervals need to be observed between other vaccinations. Different injectable inactivated vaccines should be administered into separate injection sites.
It is essential to check the antibody titer when vaccination is undertaken during treatment with immunosuppressants, and if necessary, to continue post-exposure immunization until the appearance of a protective antirabies antibody titer (≥0.5 IU/mL).
Administration of rabies immunoglobulin may be necessary for management but may attenuate the effects of concomitantly administered rabies vaccine. Therefore, it is important that rabies immunoglobulin should be administered once only for treating each at risk exposure and with adherence to the recommended dose.
Concomitant ingestion of chloroquine for malaria prophylaxis can reduce the antibody formation after intradermal administration of rabies vaccine. Therefore, the pre-exposure vaccination with VaxiRab N should be given by intramuscular route in persons using chloroquine in a concomitant manner.