Hypersensitivity to estradiol or to any of the excipients of Vagifem.
Known, past or suspected breast cancer; known or suspected estrogen-dependent malignant tumors (eg, endometrial cancer); undiagnosed genital bleeding; untreated endometrial hyperplasia; previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism); porphyria.
Use in pregnancy & lactation: Vagifem is not indicated during pregnancy. If pregnancy occurs during medication with Vagifem, treatment should be withdrawn immediately.
The results of most epidemiological studies to date relevant to inadvertent fetal exposure to estrogens indicate no teratogenic or fetotoxic effects.
Vagifem is not indicated during lactation.
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