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There are no adequate data on the use of Ursodeoxycholic acid, particularly in the first trimester of pregnancy. Ursodeoxycholic acid must not be used during pregnancy. Treatment should be discontinued immediately if pregnancy occurs and medical advice sought.
Women of childbearing potential should be treated only if they are using reliable contraception: non-hormonal or low-estrogen oral contraceptive measures are recommended. However, in patients taking Ursodeoxycholic acid for dissolution of gallstones, effective non-hormonal contraception should be used, since hormonal oral contraceptives may increase biliary lithiasis. The possibility of a pregnancy must be excluded before beginning treatment.
It is not known whether Ursodeoxycholic acid passes into breast milk. Therefore, Ursodeoxycholic acid should not be taken during lactation. If treatment with Ursodeoxycholic acid is necessary, breastfeeding must be discontinued.
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