Ursodeoxycholic acid should not be used in patients: with radio-opaque calcified gall-stones; with acute inflammation of the gall bladder or biliary tract; with occlusion of the biliary tract (occlusion of the common bile duct or a cystic duct); with frequent episodes of biliary colic; with impaired contractability of the gall bladder; with hypersensitivity to bile acids or any excipient of the formulation; who are pregnant or breastfeeding, or in women who may become pregnant; with chronic liver disease, peptic ulcers or in those with inflammatory diseases of the small intestine and colon.