The calcium in this product can interfere with the body's ability to absorb certain drugs, especially if the patient take them around the same time. These drugs include quinolone antibiotics (such as ciprofloxacin, levofloxacin), tetracycline antibiotics (such as doxycycline, minocycline), thyroid medications (such as levothyroxine), and drugs for osteoporosis (biphosphonates such as alendronate). Ask the physician how long to wait between doses and when the patient should take their medications.
Vitamin D3: The patient should avoid taking Vitamin D3 if he/she is taking the following drugs: Paricalpitol; Calcipotriene; Doxercalciferol; Mineral Oil; Orlistat; Bile acid sequestrants like colesevelam, colestipol, cholestyramine.
Drugs like Orlistat, or bile acid sequestrants like those listed as previously mentioned can decrease or prevent the body from absorbing vitamin D and other fat-dependent vitamins, namely vitamins A, E, and K.
The patient should separate Vitamin D3 from these medications by at least 2 hours or take the Vitamin D3 at bedtime to allow enough time to avoid interactions.
Also be careful with drugs like: Digoxin; Aluminum hydroxide; Water pills like chlorthalidone, hydrochlorothiazide, and chlorothiazide; Magnesium hydroxide and magnesium citrate; Fosphenytoin.
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