Triplixam Drug Interactions

Do not take aliskiren (used to treat hypertension) if patient has diabetes or kidney problems.
Avoid Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) with: Lithium (used to treat some mental disorders such as mania, manic depressive illness and recurrent depression).
Potassium-sparing drugs (e.g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, other drugs which can increase potassium in the body (such as heparin, a medicine used to thin blood to prevent clots; trimethoprim and co-trimoxazole also known as trimethoprim/sulfamethoxazole for infections caused by bacteria).
Dantrolene (infusion) (used to treat malignant hyperthermia during anesthesia (symptoms including very high fever and muscle stiffness).
Estramustine (used in cancer therapy).
Medicines, which are most often used to treat diarrhea (racecadotril) or avoid rejection of transplanted organs (sirolimus, everolimus, temsirolimus and other drugs belonging to the class of so-called mTor inhibitors).
Sacubitril/valsartan (used to treat long-term heart failure).
Other medicines used to treat high blood pressure: angiotensin-converting-enzyme inhibitor and angiotensin receptor blockers.
Special care may be required with: Other medicines for treating high blood pressure, including angiotensin II receptor blocker (ARB), aliskiren, or diuretics (medicines which increase the amount of urine produced by the kidneys).
Potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5 mg to 50 mg by day.
Anesthetic medicines.
Iodinated contrast agent.
Bepridil (used to treat angina pectoris).
Methadone (used to treat addiction).
Medicines used for heart rhythm problems (e.g. dofetilide, ibutilide, bretylium, cisapride, diphemanil, procainamide, quinidine, hydroquinidine, disopyramide, amiodarone, sotalol).
Verapamil, diltiazem (heart medicines).
Digoxin or other cardiac glycosides (for the treatment of heart problems).
Antibiotics used to treat bacterial infections (e.g. rifampicin, erythromycln, clarithromycin, sparfloxacin, moxifloxacin).
Antifungal medicines (e.g. itraconazole, ketoconazole, amphotericin B by injection).
Allopurinol (for the treatment of gout).
Antihistamines used to treat allergic reactions, such as hay fever (e.g. mizolastine, terfenadine, astemizole).
Corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis, and non-steroidal anti-inflammatory drugs (e.g. ibuprofen) or high dose salicylates (e.g. acetylsalicylic acid) (a substance present in many medicines used to relieve pain and lower fever, as well as to prevent blood clotting).
Immunosuppressants (medicines used to control the body's immune response for the treatment of auto-immune disorders or following transplant surgery) (e.g. ciclosporin, tacrolimus).
Tetracosactide (to treat Crohn's disease).
Gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis).
Halofantrine (used to treat certain types of malaria).
Baclofen used to treat muscle stiffness in diseases such as multiple sclerosis.
Medicines to treat diabetes such as insulin or metformin.
Calcium including calcium supplements.
Stimulant laxatives (e.g. senna).
Medicines for the treatment of cancer.
Vincamine (used to treat symptomatic cognitive disorders in elderly including memory loss).
Medicines to treat mental disorders such as depression, anxiety, schizophrenia (e.g. tricyclic antidepressants, antipsychotics, imipramine like antidepressants, neuroleptics such as amisulpride, sulpride, sultopride, tiapride, haloperidol, droperidol).
Pentamidine (used to treat pneumonia).
Ritonavir, indinavir, nelfinavir (protease inhibitors used to treat HIV).
Hypericum perforatum (St. John's wort).
Trimethoprim (for the treatment of infections).
Medicines used for the treatment of low blood pressure, shock or asthma (e.g. ephedrine, noradrenaline or adrenaline).
Nitroglycerin and other nitrates, or other vasodilators that may further reduce blood pressure.
Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) with food and drink: Grapefruit juice and grapefruit should not be consumed by people who are taking Perindopril arginine + lndapamide + Amlodipine (TRIPLIXAM). This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active ingredient amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of this medicine.