Triplixam Dosage/Direction for Use

Posology: One Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) film-coated tablet per day as a single dose, preferably to be taken in the morning and before a meal.
The fixed dose combination is not suitable for initial therapy.
If a change of the posology is required, titration should be done with the individual components.
Special population: Renal impairment: In severe renal impairment (creatinine clearance below 30 mL/min), treatment is contraindicated.
In patients with moderate renal impairment (creatinine clearance 30-60 mL/min), Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) at the dose 10 mg/2.5 mg/10 mg is contraindicated. It is recommended to start treatment with the adequate dosage of the free combination.
Usual medical follow-up will include frequent monitoring of creatinine and potassium.
Concomitant use of perindopril with aliskiren is contraindicated in patients with renal impairment (GFR <60 ml/min/1.73 m²).
Hepatic impairment: In severe hepatic impairment, Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) is contraindicated.
In patients with mild to moderate hepatic impairment, Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) should be administrated with caution, as dosage recommendations for amlodipine in these patients have not been established.
Elderly: Elimination of perindoprilat is decreased in the elderly.
Elderly can be treated with Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) according to renal function.
Pediatric population: The safety and efficacy of Perindopril arginine + Indapamide + Amlodipine (TRIPLIXAM) in children and adolescents have not been established. No data are available.
Method of administration: Oral use.
Missed Dose: It is important to take the medicine every day as regular treatment is more effective. However, if a dose is forgotten, take the next dose at the usual time. Do not take a double dose to make up for the forgotten dose.
Discontinuation of Treatment: As the treatment for high blood pressure is usually life-long, patient should discuss with the doctor before stopping this medicinal product.
If patient has any further questions on the use of this medicine, ask the doctor, pharmacist or nurse.