How to Use Vaginal Suppositories: Wash hands; do not open vaginal suppositories if it seems soft, hold the foil wrapper under cold water or place it in refrigerator for few minutes to harden it before removing the wrapper; remove one vaginal suppository from the strip ad hold it in fingertips; remove any foil or plastic wrapping stuck to the vaginal suppository; sit or lie down with knees bent and legs apart; gently insert the suppository into the vagina as far as comfortably possible using fingers; wash hands again.