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Pharmacology: Pharmacodynamics: TRIMIC (Metronidazole + Miconazole Nitrate) vaginal suppository contains metronidazole for antibacterial and antitrichomonal effects and miconazole for antifungal action.
Miconazole nitrate has a wide spectrum of activity. It is particularly effective against pathogen fungi including Candida albicans, in addition to Gram (+) bacteria. Metronidazole is an antibacterial and antiprotozoal agent that is effective against several infections caused by anaerobic bacteria and protozoa such as Gardenerella vaginalis, Trichomonas vaginalis and anaerobic bacteria including anaerobic Streptococci.
Pharmacokinetics: Absorption of miconazole nitrate through the intravaginal route is very low (approximately 1.4% of dose). Bioavailability of metronidazole by this route is 20% compared to the oral route. Steady state level of metronidazole in plasma reaches 1.6-7.2 μg/mL.
Metronidazole is metabolized in the liver. The hydroxyl-metabolite is effective. The half-life of metronidazole is 6-11 hours. Approximately 20% of the dose is excreted unchanged in urine.
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