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Symptoms: Overdosage may lead to muscular hypotonia, drowsiness, respiratory depression, coma and convulsions.
Treatment: Treatment of overdosage is symptomatic. Consideration should be given to gastric lavage and/or the use of activated charcoal in patients who have ingested >100 mg within 1 hr of presentation; activated charcoal is recommended in children who have taken >5 mg/kg or 100 mg within the last hr. Observation should continue for at least 6 hrs after ingestion.
Atropine sulfate 600 mcg IV was used to treat a patient who had ingested 420 mg of baclofen and had failed to improve after gastric lavage and induced diuresis.
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