Trilaxant Dosage/Direction for Use

The initial dose is 5 mg thrice daily for 3 days, increased to 10 mg thrice daily for 3 days, then in similar increments and intervals until either a dose of 20 mg thrice daily is reached or until the desired therapeutic effect is obtained. Higher doses have been used.
Doses >80-100 mg daily are not generally recommended, although doses of up to 150 mg daily have been given to carefully supervised patients.
Children >10 years: A maximum daily dosage of 2.5 mg/kg may be given. It is usual to start with a low dose of 2.5 mg given 4 times daily, increased cautiously about every 3 days until the desired therapeutic effect is obtained. Recommended Daily Maintenance Doses: 6-10 years: 30-60 mg; 2-6 years: 20-30 mg; 12 months to 2 years: 10-20 mg.
Elderly: Lower initial doses should be given, although final maintenance doses maybe in the same range as younger adults.
Renal Impairment/Patients Undergoing Chronic Hemodialysis: Doses of baclofen should be reduced to 5 mg daily as suggested. If no benefit is apparent within 6 weeks of achieving the maximum dosage, therapy should probably be gradually withdrawn.
Administration: Baclofen is given by mouth in divided doses, preferably with or after food or milk.