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Pharmacology: Pharmacodynamics/Pharmacokinetics: Levofloxacin is rapidly absorbed almost completely absorbed following oral use peak plasma concentration within 1 to 2 hours. It is widely distributed into body tissue including the bronchial mucosa and lungs, but penetration into the CSF is relatively poor. Levofloxacin is approximately 30 to 40% bound to plasma proteins.
It is only metabolized to a small degree to inactive metabolism. The elimination half-life of levofloxacin is 6 to 8 hours. Although this may be prolonged in patients with renal impairment.
Levofloxacin is excreted largely unchanged primarily in the urine. It is not removed by haemodialysis or peritoneal dialysis.
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