Tenelizone Drug Interactions

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Full Prescribing Info

Drug Interactions

Teneligliptin is metabolized by (FMO3 and FMO1) flavin-containing monooxygenase and CYP3A4 primarily; this drug was 14.8 to 22.1% is urinary excretion of unchanged drug: See Table 2.

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Co-administration of Pioglitazone with gemfibrozil (an inhibitor of cytochrome P450 2C8) is reported to result in a 3-fold increase in AUC of Pioglitazone. Since there is a potential for an increase in dose-related adverse events, a decrease in the dose of Pioglitazone may be needed when gemfibrozil is concomitantly administered. Close monitoring of glycemic control should be considered.
Co-administration of Pioglitazone with rifampicin (an inducer of cytochrome P450 2C8) is reported to result in a 54% decrease in AUC of Pioglitazone. The Pioglitazone dose may need to be increased when rifampicin is concomitantly administered. Close monitoring of glycemic control should be considered.

Manufacturer:

Ajanta Pharma Phil

Distributor:

Ajanta Pharma Phil