Tenelizone Contraindications

Teneligliptin plus Pioglitazone tablet is contraindicated in patients with hypersensitivity to the active substances or to any of the excipients. The combination tablet is also contraindicated in patients with diabetic ketoacidosis, diabetic pre-coma; moderate and severe renal impairment (creatinine clearance < 60 mL/min); acute conditions with the potential to alter renal function such as dehydration, severe infection, shock, intravascular administration of iodinated contrast agents, current bladder cancer or a history of bladder cancer and uninvestigated macroscopic hematuria. Administration of combination is not suitable for severe infection, before and after surgery, glycemic control by insulin injection.
The combination is also contraindicated in acute or chronic disease which may cause tissue hypoxia such as cardiac or respiratory failure, recent myocardial infarction, shock, hepatic impairment, acute alcohol intoxication, alcoholism and during pregnancy and lactation.