TDL Dosage/Direction for Use

TDL capsule: The dosage depends on the intensity of the pain and the sensitivity of the individual patient. The total daily dosage by mouth should not exceed 400 mg.
Usual doses by mouth are 50 to 100 mg every 4 to 6 hours.
TDL ampoule: A dose of 50 to 100 mg may be given every 4 to 6 hours by intravenous injection over 2 to 3 minutes, or by intravenous infusion.
For treatment of postoperative pain, the initial dose is 100 mg followed by 50 mg every 10 to 20 minutes if necessary to a total maximum (including the initial dose) of 250 mg in the first hour. Thereafter, doses are 50 to 100 mg every 4 to 6 hours to total daily dose of 600 mg.
The dosage interval should be increased to 12 hours in patients with a creatinine clearance less than 30 mL per minute. The maximum dose by mouth should not exceed 200 mg daily in these patients.
Tramadol should not be given to patients with more severe renal impairment (creatinine clearance less than 10 ml per minute). A dosage interval of 12 hours is also recommended in severe hepatic impairment.