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Tramadol may produce fewer typical opioid adverse effects such as respiratory depression and constipation. In addition to hypotension, hypertension has occasionally occurred. Anaphylaxis, hallucinations and confusion have also been reported.
Effects on the respiratory system: Respiratory depression has been reported after tramadol infusion anesthesia although in a postoperative study tramadol had no significant respiratory depressant effect when equianalgesic doses of morphine, pentazocine, pethidine, piritramide and tramadol were compared.
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