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Tapcom-S: No interaction studies have been performed.
There is a potential for additive effects resulting in hypotension and/or marked bradycardia when ophthalmic beta blockers solution is administered concomitantly with oral calcium channel blockers, beta-adrenergic blocking agents, antiarrhythmics (including Amiodarone), digitalis glycosides, parasympathomimetics, Guanethidine.
Oral β-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of Clonidine.
Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g. Quinidine, Fluoxetine, Paroxetine) and Timolol.
Mydriasis resulting from concomitant use of ophthalmic beta-blockers and adrenaline (Epinephrine) has been reported occasionally.
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