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In general, phenoxymethylpenicillin has low toxicity. Clinical features of overdose may include GI symptoms such as nausea and vomiting. In patients with renal impairment, the drug may accumulate in the blood, and the dose should be adjusted accordingly.
In case of overdosage, the cardiovascular status, electrolyte balance and renal function should be monitored. Penicillins are not readily removed by dialysis.
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