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Tab 1 g: Sign and Symptoms: Gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Amoxicillin crystalluria, in some cases leading to renal failure, has been observed.
Treatment: GI symptoms may be treated symptomatically, with attention to the water/electrolyte balance. Co-amoxiclav can be removed from the circulation by hemodialysis.
Children (additional statement): A prospective study of 51 pediatric patients at a poison control center suggested that overdosages of less than 250 mg/kg of amoxicillin are not associated with significant clinical symptoms and do not require gastric emptying.
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