Clindamycin 1% Topical Solution with Vitamin E is for dermatological use only. Concomitant topical pimple/acne therapy should be used with caution because of the possible cumulative irritancy effect that may occur, especially with the use of peeling, desquamating, or abrasive agents. Avoid contact with eyes and mucous membranes. Use of topical formulation of Clindamycin results in absorption of the antibiotic from the skin surface, and has reported usually of diarrhea and colitis.