Solu-Medrol Description

This product contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate USP, occurs as a white, or nearly white, odorless hygroscopic, amorphous solid, it is very soluble in water and in alcohol. It is insoluble in chloroform and is very slightly soluble in acetone.
The chemical name for methylprednisolone sodium succinate is pregna-1, 4-diene-3, 20-dione, 21-(3-carboxy-1-oxopropoxyl-11), 17-dihydroxy-6-methyl monosodium salt, (6α,11β).
Methylprednisolone sodium succinate is so extremely soluble in water that it may be administered in a small volume in situations in which high blood levels of methylprednisolone are required rapidly.
Methylprednisolone Sodium Succinate (Solu-Medrol) is available in several strengths and packages for intravenous or intramuscular administration.
Act-O-Vial System (Single-Dose Vial): 125 mg Powder for Injection with 2 mL diluent (DRP-2128): Each vial approximately contains methylprednisolone sodium succinate equivalent to 125 mg of Methylprednisolone, USP. Diluent in the upper compartment of the Act-O-Vial contains Water for Injection.
40 mg Powder for Injection with 1 mL diluent (DRP-2156): Each vial approximately contains methylprednisolone sodium succinate equivalent to 40 mg of Methylprednisolone, USP. Diluent in the upper compartment of the Act-O-Vial is Bacteriostatic Water for Injection, USP containing 0.9% w/v benzyl alcohol as preservative.
40 mg Powder for Injection with 1mL diluent (DRP-7404): Each vial approximately contains methylprednisolone sodium succinate equivalent to 40 mg Methylprednisolone, USP. Diluent in the upper compartment of the Act-O-Vial is Water for Injection.
Vial (with diluent packaged in a separate vial): 500 mg Powder for Injection with 8 mL diluent (DRP-2157): Each vial approximately contains methylprednisolone sodium succinate equivalent to 500 mg Methylprednisolone, USP. Diluent is Bacteriostatic Water for Injection, USP containing 0.9% w/v benzyl alcohol as preservative.
1 g Powder for Injection with 15.6 mL diluent (DRP-2155): Each vial approximately contains methylprednisolone sodium succinate equivalent to 1 g Methylprednisolone, USP. Diluent is Bacteriostatic Water for Injection, USP containing 0.9% w/v benzyl alcohol as preservative.
Excipients/Inactive Ingredients: 40 mg Powder for Injection (in Act-O-Vial) (DRP-2156): Drug Product: Monohydrate Monobasic Sodium Phosphate, Dried Dibasic Sodium Phosphate, Lactose, Sodium Hydroxide, Water for Injection.
Diluent: Benzyl alcohol, Water for Injection.
40 mg Powder for Injection (in Act-O-Vial) Preservative-Free (DRP-7404): Drug Product: Anhydrous Monobasic Sodium Phosphate, Dried Dibasic Sodium Phosphate, Lactose, Sodium Hydroxide, Water for Injection.
Diluent: Water for Injection.
125 mg Powder for Injection (in Act-O-Vial) (DRP-2128): Drug product: Anhydrous Monobasic Sodium Phosphate, Dried Dibasic Sodium Phosphate, Sodium Hydroxide, Water for Injection.
Diluent: Water for Injection
500 mg Powder for Injection (DRP-2157): Drug Product: Anhydrous Monobasic Sodium Phosphate, Dried Dibasic Sodium Phosphate, Sodium Hydroxide, Water for Injection.
Diluent: Benzyl alcohol, Water for Injection.
1 g Powder for Injection (DRP-2155): Drug Product: Monohydrate Monobasic Sodium Phosphate, Dried Dibasic Sodium Phosphate, Sodium Hydroxide, Water for Injection.
Diluent: Benzyl alcohol, Water for Injection.