Silvederma Use In Pregnancy & Lactation

A reproductive study was carried out in rabbits at doses three to ten times the concentration of silver sulfadiazine in SILVEDERMA cream and no harm to the fetus due to the silver sulfadiazine content was detected. However, there are no adequate and well controlled studies in pregnant women.
Since reproductive studies in animals are not always predictive of human response, this drug should be used during pregnancy only if it is clearly justified, especially in pregnant women approaching or at term.
It is not known if silver sulfadiazine is excreted in human milk. However, sulfonamides are known to be excreted in human milk and that all sulfonamide derivatives increase the possibility of kernicterus.
Because of the possibility of serious adverse reactions from sulfonamides in nursing infants, a decision should be made to either discontinue nursing or to discontinue the treatment, taking into consideration the importance of the drug to the mother.