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Sevoflurane should not be used in patients with known or suspected genetic susceptibility to malignant hyperthermia.
Sevoflurane should not be used in patients with known or suspected sensitivity to sevoflurane or to other halogenated inhalational anesthetics (e.g. history of hepatotoxicity, usually including elevated liver enzymes, fever, leukocytosis and/or eosinophilia temporally related to anesthesia with one of these agents).
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