Sevorane Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Sevoflurane

Indications/Uses

Induction & maintenance of general anesth in adult & ped patient for inpatient & outpatient surgery.

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Dosage/Direction for Use

Induction: Individualized dosage. Adult & childn Inspired conc of up to 8% in <2 min w/ O₂ or O₂-nitrous oxide mixt. Maintenance: 0.5-3% w/ or w/o concomitant use of nitrous oxide.

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Overdosage

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Contraindications

Hypersensitivity to other halogenated anesth. Known or suspected genetic susceptibility to malignant hyperthermia.

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Special Precautions

May cause resp depression. Pre-op hyperkalemia especially in patients w/ latent & overt neuromuscular disease, particularly Duchenne muscular dystrophy. QT prolongation, ventricular arrhythmia (ped w/ Pompe's disease). Patients w/ mitochondrial disorders. Malignant hyperthermia. Seizures. Maintain hemodynamic stability in CAD patients. Risk for ICP elevations. Not recommended in concomitant use w/ KOH containing CO2 absorbents. May increase potential for hepatic injury. Severe hepatic dysfunction. Renal insufficiency. May impair ability to drive or operate machinery. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Agitation; bradycardia; hypotension; cough; nausea. Somnolence, dizziness, headache; tachycardia; HTN; resp disorder, laryngospasm; salivary hypersecretion; chills, pyrexia; abnormal blood glucose, LFT, WBC, increased fluoride; hypothermia.

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Drug Interactions

Potential risk of ventricular arrhythmia w/ α- & β-sympathomimetic agents (eg, isoprenaline, adrenaline & noradrenaline). Risk of crisis during an operation w/ non-selective MAOIs. May lead to marked hypotension or risk of additive -ve inotropic effect w/ Ca antagonist. Rare increases in serum K levels w/ succinylcholine. Decreased MAC w/ benzodiazepines, nitrous oxide & opiates. Increased metabolism w/ CYP2E1 inducers (eg, INH & alcohol). Increased intensity & duration of neuromuscular blockade w/ nondepolarizing muscle relaxants eg, pancuronium, vecuronium or atracurium.

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Storage

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Description

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Action

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MIMS Class

Anaesthetics - Local & General

ATC Classification

N01AB08 - sevoflurane ; Belongs to the class of halogenated hydrocarbons. Used as general anesthetics.

Regulatory Classification

Presentation/Packing

Form

Sevorane liqd for inh

Packing/Price

250 mL x 1's

Sevorane

sevoflurane

Manufacturer:

Abbvie

Distributor:

Zuellig