Seroalbumin Dosage/Direction for Use

The concentration of the albumin preparation, dosage and the infusion-rate should be adjusted to the patient's individual requirements.
The choice of albumin rather than artificial colloid will depend on the clinical situation of the patient, based on official recommendations.
Posology: In general, dosage and infusion rate should be adjusted to the patient's individual requirements. When human albumin is used in replacement therapy, the dosage required is guided by the usual circulatory parameters.
The lowest limit for colloidal osmotic pressure is 20 mmHg (2.7 kPa).
If albumin is to be administered, the dose in grams required can be estimated using the following calculation: [required total proteins (g/L) - actual total proteins (g/L)] x plasma volume (L) x 2.
The physiological plasma volume may be calculated as approximately 40 mL/kg of body weight. In case of extensive substitution therapy and in cases with haematocrit below 30% (see Precautions).
Pediatric Use: The fact that in children the physiological plasma volume is age-dependent should be taken into account.
Method of Administration: Human Albumin is ready for use and is to be administered by intravenous infusion only.
The infusion rate should be adjusted according to individual circumstances and indications, normally be set at 1-2 mL/min.
Maximum time for administration is 3 hours. Infusion rate should not exceed 30 mL/min during plasmapheresis.
If large volumes are to be administered, the product should be warmed to room or body temperature before use.
When suggested by clinical indications, Human Albumin can be diluted with 0.9% NaCl solution and 5% or 10% glucose solutions.